Low Dose Naltrexone

How does Low Dose Naltrexone work?

Low Dose Naltrexone (LDN) works by increasing the body’s release of endorphins, which decreases the inflammation pathways in the brain. This can also decrease the immune system’s inflammatory response to your body’s healthy tissues.

However, LDN is not just a treatment for inflammation. It also has been effective with improving mood, reducing inflammation, and improving digestion.

Studies show that LDN treatment can manage chronic pain associated with conditions such as fibromyalgia and help treat disorders such as Crohn’s disease. Generally, treatment with LDN results in overall symptom improvement and better functioning.

Low Dose Naltrexone

Conditions Treated by Low Dose Naltrexone

  • Fibromyalgia
  • Certain types of cancers
  • Ulcerative colitis
  • Crohn’s disease
  • Lyme disease
  • Depression and Anxiety
  • Cardiomyopathy
  • Multiple sclerosis
  • Rheumatoid arthritis
  • Chronic pain
  • Hashimoto’s thyroiditis
  • Kawasaki’s disease
  • Epstein Barr virus
  • Pernicious anemia
  • Lupus 
  • Scleroderma
  • Menopause/PCOS/PMDD

Good News About Low Dose Naltrexone

  • Low cost. Naltrexone is a generic medication therefore it is relatively inexpensive. However, this is a medication that needs to be compounded.
  • Little to no side effects. Side effects of LDN are generally mild. If anything, vivid dreams might be experienced in the first few doses, but then will lessen over time.


Low Dose Naltrexone Trust

Younger J, Parkitny L, McLain D. The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clin Rheumatol. 2014;33(4):451-459. doi:10.1007/s10067-014-2517-2

Kim PS, Fishman MA. Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review. Curr Pain Headache Rep. 2020 Aug 26;24(10):64. doi: 10.1007/s11916-020-00898-0. PMID: 32845365.

Patten DK, Schultz BG, Berlau DJ. The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn’s Disease, and Other Chronic Pain Disorders. Pharmacotherapy. 2018 Mar;38(3):382-389. doi: 10.1002/phar.2086. Epub 2018 Feb 23. PMID: 29377216.

Weinstock LB, Brook JB, Myers TL, Goodman B. Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment. BMJ Case Rep. 2018;2018:bcr2017221405. Published 2018 Jan 11. doi:10.1136/bcr-2017-221405

Cabanas H, Muraki K, Eaton-Fitch N, Staines DR, Marshall-Gradisnik S. Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment. Front Immunol. 2021;12:687806. Published 2021 Jul 13. doi:10.3389/fimmu.2021.687806

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